The Gell and Coombs's classification divides drug allergies into four pathophysiological types, namely anaphylaxis (type I), antibody-mediated cytotoxic reactions (type II), immune complex-mediated reactions (type III), and delayed type hypersensitivity (type IV). Although this classification was proposed more than 30 years ago, it is still.. Paper: Classification of allergic reactions responsible for clinical hypersensitivity and disease Robin Coombs and Philip Gell Clinical Aspects of Immunology , PGH Gell and RRA Coombs (eds), Blackwell Scientific, Oxford, 1968
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Gell and Coombs classified hypersensitivity reactions into four 'types'. I suggest that the premise that these reactions represent 'hypersensitivity' manifestations is limiting and that they represent four major strategies that the body uses to combat infectious agents. I further propose that there is a fifth strategy that was not envisioned in the Gell and Coombs classification.. Il existe également des allergies plus rares et souvent plus graves. La classification des allergies proposée en 1963 par les immunologistes britanniques Robin Coombs et Philip Gell est un système qui catégorise les réactions d'hypersensibilité en quatre types principaux. Voici une description plus détaillée de chaque type :